Stoke will have to win in the Mestalla next week if their European adventure is to continue after Valencia claimed a 1-0 win in the first leg of their Europa League last-32 clash at the Britannia Stadium.
Mehmet Topal netted the only goal of the game in the 36th minute with a stunning 30-yard strike that gave Asmir Begovic no chance.
Sofiane Feghouli also hit the post in the second half while Stoke, who have lost their last four Barclays Premier League games, were limited to half-chances.