England fast bowler Graham Onions has been ruled out of the whole Test series against Bangladesh due to a back injury which has forced him to fly home.
The 27-year-old had initially been ruled out of the first Test in Chittagong, but is now a definite absentee for the second game in Mirpur.
England skipper Alastair Cook confirmed: "I'm desperately disappointed for him.
"He was a huge part of our plans and he still is, obviously, because of the way he bowled in South Africa, where he was unlucky not to take more wickets than he did.
"He bowled really well there, and I was expecting him come to these conditions and bowl well here as well.
"But these things happen, and luckily we've got the strength in depth in our seam-bowling unit to be able to cope.
"The MRI scan didn't show too much structural damage, so it does look like a short-term thing.
"But these matches come so quickly and he hasn't had any proper bowling on this tour, so we couldn't see how, physically, he could be ready.
"If he was fit, he wouldn't be match-fit to play in the next Test match, so there's obviously no point in him being here."