"There will be changes, and I could do whatever I want in terms of selection," the former Manchester United winger told Reading's official website.
"I don't like to change a winning team, so when we lose it's only right that to do what I see fit.
"Only Marcus (Hahnemann, the goalkeeper) came out of Fulham with any credit to be honest."
And Coppell insists he is looking forward to facing Arsenal, which he describes as a 'no-lose' game.
He said: "I'm always saying that the games against the elite teams are no-lose situations because not many teams around you are likely to pick up points there.
"Everybody says it's nigh-on impossible, but for every single game I think we are capable of winning, that's my mentality.
"I will feel that again when the game comes around."